The Potential Application of Natural Ingredient Ivy Extract Hederagenin in Health Products

As A aleading supplier specialising danshigh-quality plant extracts, Green Spring Technology continues to focus on natural active ingredients with markEt etpotentiAl., Et etal.Recent scientific studies have focused on hederagenin—A anatural pentacyclic triterpenoid compound Et en plusits derivatives derived from plants such En tant queChinese ivy—revealing its excellent health application prospects Et en plusproviding strong scientific support for formula innovation dansLe conseil des ministresfields De lahealth supplements, functional foods, Et en plusbeverages.

Hederageninis a pentacyclic triterpenoid compound primarily derived from plants such as Chinese ivy, Cynanchum atratum, Patrinia scabiosaefolia, Paeonia lactiflora, and Acanthopanax senticosus, typically existing in the form De lasaponins or saponins [1].......Hederageninextracted from ivy exhibits various biological activities.

1 Research on the relationship between Hederageninand inflammatory responses

Experimental evidence indicates that Hederagenin can effectively downregulate the expression De lamultiple pro-inflammatory cytokines (such as TNF-α, IL-6, TGF-β1), which play important roles in chroniqueinflammation and the progression of various diseases.

Inflammation is a complex physiological response of the body to inflammatory factors, involving multiple cellular and molecular mechanisms. Zhang Et al.[2] found that Hederagenin may contribute to respiratory health and is associated with the regulation of the transient récepteurpotential (TRP) channel pathway.

Li Et etAl., Et etal.[3] explored the potential association between Hederagenin and the NF-κB signalling pathway. Experimental data suggest that this compound may participate in La réglementationthe cellular localisation of NF-κB and Smads proteins and may influence the expression levels of downstream molecules such as transforming growth factor β1 (TGF-β1). These findings provide new insights into the mechanisms underlying Hederagenin's role in inflammatory responses.

In the study Par:Ma Et etAl., Et etal.[4], interactions between Hederagenin and the Ras protein/Jun N-terminal kinase/T-cell transcription factor 4 signalling axis were observed. Experimental data showed that the expression levels of factors such as tumour necrosis factor α, IL-6, transforming growth factor β1, and connective tissue growth factor in the serum of rats treated with this compound exhibited a downward trend, while the pathological characteristics of lung tissue also changed.

Wang and Zhao au[5] explored the potential association between Hederagenin and the NOD-likereceptor protein 3 inflammasome and NF-κB pathway. Experimental results indicate that this compound may influence the phosphorylation process of the NF-κB pathway and is associated with the expression regulation of the NOD-like receptor protein 3 inflammasome. In a lipopolysaccharide-induced acute lung injury model, changes in the polarisation state of macrophages were observed in the compound-treated group.

Lee Et etAl., et al.[6] found that the expression of NF-κB signalling pathway-related molecules was altered in the Hederagenin-treated group. Experimental data suggest that this compound may participate in regulating the expression of inflammatory factors such as nitric oxide synthase and cyclooxygenase-2.

Kim et Al., et al.[7] investigated the role of Hederagenin in an alcoholic liver injury model, and experimental data showed changes in the expression levels of inflammatory mediators in the Hederagenin-treated group. Shen et Al., et al.[8] observed a potential association between Hederagenin and the tyrosine kinase 2/signal transduction and transcription activator (STAT)3/MAPK signalling pathway, while also detecting changes in the expression levels of inflammatory-related cytokines.

Yu et Al., et al.[9] demonstrated that Hederagenin may participate in regulating signaling pathways such as NF-κB, MAPK, and phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt). Experimental results showed differences in the gene expression levels of apoptosis-related markers and inflammatory cytokines in the treatment group.

These studies suggest that Hederagenin may interact with multiple inflammation-related signalling pathways, with factors such as the IL family and tumour necrosis factor α potentially serving as regulatory targets in its action process.

2 Research Progress on Hederagenin Derivatives from Ivy Extracts

Due to the limitations of Hederagenin's physicochemical properties, researchers have explored its derivatives. Among these, α-Hederagenin, as a natural product molecule, has received significant attention [22].

Fang et al. [27] found that the expression of Sirtuin 6 protein changed in the α-Hederagenin-treated group, and simultaneously observed alterations in the expression levels of hypoxia-inducible factor 1α and c-Myc genes, which are regulators of glycolysis. Experimental data showed that the expression levels of glycolysis-related proteins also exhibited corresponding changes.

A propos de nouset al. [28] investigated the potential association between α-Hederagenin and the glutathione synthase/glutathione/glutathione peroxidase 2 system. Experimental results indicated that this compound may influence the oxidative stress state of non-small cellulesand exhibit certain interactions with cisplatin [29-30].

Chen et al. [31] revealed a potential link between α-Hederagenin and the Hippo signalling pathway. Data showed that the phosphorylation levels of Yes-related protein upstream kinase macrophage-stimulated 1 and L-type amino acid transporter were altered in the compound-treated group, while the cellular localisation of Yes-related protein also changed.

3 Broad Application Prospects

Existing research has explored Hederagenin and its derivatives from ivy extracts in multiple aspects. Hederagenin, an ivy saponin, demonstrates application potential in various health fields and may be suitable for developing functional products in the following areas:

respiratory health support, joint comfort and health, liver protection, neural health and protection, metabolic and oxidative stress regulation, etc.

Green Spring Technology is committed to providing customers with high-quality raw materials based on scientific research. We deeply understand the importance of plant extract raw materials in end products. Green Spring Technology has a strict quality control system to ensure the purity, active ingredient content, and batch-to-batch stability of raw materials.

Our production and quality management systems strictly adhere to international standards (EP, USP, JP), ensuring that products comply with regulatory requirements in major export markets.

Customised solutions:We can provide Ivy Leaf Extract Powder Hederagenin-related raw materials in different specifications and with stability support to assist you in developing new product formulations based on your specific needs.

Please contact us at helen@greenspringbio.com.

Référence:

[1]Zeng:J,Huang HuangT,Xue M.et al.connaissances actuelles et développement de hederagenin as  a  prometteur Agent médicinal :a Examen complet [J]. RSC Adv, 2018, 8(43) : 24188-24202. DOI: 10. Les femmes 1039/ c8ra03666g.

[2]Zhang D, Le soleil J, J, Le Yang B,  et  al.   thérapeutique effet De tetrapanax papyriferus et hederagenin sur la douleur neuropathique chronique d’une lésion de constriction chronique of  sciatique Rats nerveux basés sur koeuf Prévision des voies et vérification expérimentale [J].  Basé sur Evid Complément alteratMed,2020,2020 :2545806. DOI: 10. 1155/2020/2545806.

[3]Li Y, Dong J, Shang Y, et al.   Effets anti-inflammatoires de heder- agenin sur la cardiomyopathie diabétique via l’inhibiation des voies de signalisation NF-κB et Smads dans un modèle de souris diabétiques de type 2 [J]. RSC Adv, 2019, 9(45) : 26238-26247. DOI: 10. Les femmes 1039/c9ra02043h.

[4]Ma W, Huang  Q, À propos de nous G, et  al.   Le conseil des ministres protection effet De heder- agenin on pulmonaire fibrose by  regulating  L’axe Ras/JNK/NFAT4 chez le rat [J]. Biosci est une société de droit international privé. Les biotechnologies Biochem, 2020, 84 (6) : 1131 -1138. DOI: 10. Les femmes 1080/09168451. En 2020. 1721263.

[5]Wang L,  Zhao  M. :   La Suppression of  NOD-like  receptor  Activation de l’inflammasome de protéine 3 et macrophage M1 La polarisation par heder- agenin contribue à atténuer les lésions pulmonaires aiguës induites par la sepsie chez le rat [J].  Bioingénierie, 2022, 13 (3) Téléphone: 7262-7276.  DOI:  10. Les femmes 1080/21655979. En 2022. 2047406.

[6]Lee CW, Le parc Le SM, Zhao R, et  al.   Hederagenin, a  Composante majeure de clématites  mandshurica  M. Ruprecht  Racine,  atténue  Réponses inflammatoires dans RAW 264. 7 cells  and  Chez la souris [J].   Int Int Immunop- harmacol, En 2015, 29 (2) : 528-537.   DOI:  10. Les femmes  1016/j.  Intimp. En 2015. 10. Les femmes 2. Les droits de l’homme.

[7]Kim GJ, La chanson Fr, fr, it, nl À propos de nous HS, et  al.   Hederagenin  La supplémentation atténue la réponse pro-inflammatoire et apoptotique à l’alcool chez le rat [J]. Nutriments, 2017, 9(1) : 41. DOI: 10. Les femmes 3390/nu9010041.

[8]Shen Y, Teng L, Qu Qu Y, et  al.   Hederagenin  supprime Inflammation et dégradation du cartilage pour améliorer la progression de l’arthrose: une in vivo and  in  In vitro Étude [J].   L’inflammation, 2023, 46 (2) :  655 678. DOI: 10. Les femmes 1007/s10753-022-01763-5.

[9]Yu H, chanson L,Cao X,et al.Hederagenin atténue Ischémie cérébrale/blessure de reperfusion par régulation MLK3 Signalisation.  Avant pharmacol[J]. Avant Pharmacol, 2020, 11:1173. DOI: 10. Les femmes 3389/ fphar. En 2020. À partir de 01173.

[10]Lin Rm,Liu L,Silva M,et al.Hederagenin protège Cellules PC12 contre les lésions induites par la corticosterone par l’activation de la voie PI3K/ AKT [J].Front Pharmacol,2021,12:712876. DOI: 10. Les femmes 3389/fphar. 20e année. 712876.

[11]Liang BF,Huang F,Wang HT,et Al.implication du système de noradrénaline et de sérotonine dans les antidépresseurs semblables Les effets De hederagenin à the   rat  modèle of  imprévisible  chronic   doux  Dépression induite par le stress [J]. Pharm Biol, 2015, 53 (3) Téléphone: 368-377.   DOI:  10. Les femmes 3109/13880209. 2014. Les droits de l’homme. 922586.

[12]Wu Sa, Zeng  L, l, Wong VK,  et  al.   Hederagenin  and  α-hederin favorisent la dégradation De protéines in  neurodégénérative Les maladies Et améliorer les déficits moteurs chez les souris MPTP [J].  Pharmacol Res, 2017, 115:25-44.  DOI: 10. Les femmes 1016/j. PHRS. 2016, année internationale des droits de l’homme. 11. Les femmes 2. Les droits de l’homme.

[13]Xie ZS, Zhao JP, Wu  L, l et  al.   Hederagenin améliore la maladie d’alzheimer À travers  PPARα/ tfeb médié Autophagie [J] .    Phyto- médecine, 2023, 112:154711.  DOI:  10. Les femmes 1016/j. Phymed. 2023. Les droits de l’homme 154711.