Poudre de chlorhydrate de berbérine

Qu’est-ce que la poudre de chlorhydrate de berbérine?

Le chlorhydrate de berbérine est un alcaloïde d’isoquinoléine avec diverses activités extraites des rhizomes de plantes telles que Huanglian, l’écorce de Phellodendron, et Sanguisorbia. Il a les fonctions d’élimination de la chaleur, de désintoxication et de la diarrhée, et est largement utilisé dans la médecine traditionnelle chinoise. Son application clinique initiale était principalement à des fins antibactériennes.

 En tant qu’ingrédient actif dans le traitement de l’inflammation du tractus gastro-intestinal, le chlorhydrate de berbérine a également montré une bonne efficacité dans le traitement de la dysenterie et de la diarrhée due au syndrome du côlon irritable. Il a été largement utilisé en vente libre pour lutter contre la dysenterie. Il a également des effets importants dans la régulation de la glycémie et du métabolisme des lipides, la prévention de l’athérosclérose, l’antiarythmie, l’inhibition de la prolifération des cellules tumorales et les anti-virus.

Green Spring Technology fournit 98% de poudre de chlorhydrate de berbérine ou de granulés. Nous fournissons du chlorhydrate de berbérine à partir de Coptis Chinensis ou Phellodendron chinense Schneid. C’est une API naturelle.

Green Spring Technology est une société de biotechnologie leader en Chine, qui a été fondée en 2000 et se consacre à fournir des extraits de plantes naturels, sûrs et biologiques à ses clients. Il a obtenu de nombreuses certifications telles que Halal, casher, COSMOS, BRC, IFS, FDA, ISO9001, ISO22000, et ainsi de suite. Green Spring dispose d’un système de gestion de la qualité interne systématique et organise la production selon les normes ISO, HACCP et autres normes de qualité. Les produits sont conformes aux normes ue EC396, ue 2023/915 et aux normes les plus élevées en matière de résidus de solvants. 

Spécification:  

Règlement:

Il est conforme à la réglementation de l’ue.

Benefits:

Bacterial Inhibition

The Chinese medicine Berberine Hydrochloride has the effect of clearing heat and removing toxins, and it has been used for thousands of years to treat diarrhoea. Berberine Hydrochloride (Berberine Complex) can fully exert its inhibitory effect on intestinal bacteria such as Shigella dysenteriae, Shigella fumigatus, Salmonella, and Staphylococcus aureus, and at the same time, it maintains the intestinal microenvironmental homeostasis as well as protects the mucous membranes of the gastrointestinal tract, thus resolving diarrhoea caused by intestinal infections.

Hypoglycaemic

Under the stimulation of glucose, berberine hydrochloride can increase insulin secretion and cell proliferation in MIN6 islet cells, which can act as an insulinotropic agent; berberine hydrochloride can also activate the adenosine phosphate-activated protein kinase signalling pathway to restore damaged islet cells and promote insulin secretion in rats.

Berberine hydrochloride can effectively inhibit the production of pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha, modulate the expression of insulin receptor substrate 1 and serine/threonine kinase phosphorylation, thus improving the insulin signalling cascade and insulin resistance. It has the application prospect of assisting in the control of blood glucose.

Anti-Inflammatory

Berberine hydrochloride has significant anti-inflammatory effects, mainly through inhibiting the production and activity of inflammatory factors. In a variety of inflammatory diseases, berberine hydrochloride tablets can exert excellent anti-inflammatory effects, such as gastroenteritis, pneumonia and so on. Berberine hydrochloride can effectively inhibit the adhesion of leukocytes, the activation of NF-κB, and the production and release of inflammatory factors such as TNF-α, IL-1β, IL-6, TGF-β, and IL-8.

Beneficial to Cardiovascular Health

Berberine hydrochloride has been widely studied in cardiovascular diseases, as K+ channels, Ca+ channels, cholinesterase, M receptors, adenosine receptors, etc. can be targeted by berberine hydrochloride, therefore, berberine hydrochloride is also a valuable lead compound for cardiovascular diseases and has a promising application.

Antihypertensive

The mechanism of action of safranin in antihypertension is mainly to competitively block the α-receptor of vascular smooth muscle, to reduce peripheral vascular resistance; in addition, it can also enhance the action of acetylcholine through the activity of anticholinesterase, to make the vasodilatation.

Reduces Blood Glucose

Berberine hydrochloride inhibits mitochondrial glucose oxidation and stimulates glycolysis, subsequently increasing glucose metabolism; it reduces ATP levels by inhibiting mitochondrial function in the liver. It inhibits the activity of DPP 4 (a ubiquitous serine protease), which cleaves certain peptides, and they act to increase insulin levels in the presence of high blood sugar. Berberine hydrochloride has beneficial effects on improving insulin resistance and glucose utilization in tissues by lowering lipid (especially triglyceride) and plasma free fatty acid levels.

Antioxidant

The metabolites of berberine hydrochloride and berberine have been shown to display excellent -OH scavenging activity, which is roughly comparable to that of vitamin C, a potent antioxidant. An increase in SOD (superoxide dismutase) activity and a decrease in MDA (a marker of lipid peroxidation) levels were monitored when berberine was administered to rats modeled with diabetes. Further results showed that the scavenging activity of berberine is closely related to its ferrous ion chelating activity, and the C-9 hydroxyl group of berberine is an essential part.

Applications:

In Pharmaceutical:

Berberine Hydrochloride Powder as a natural ingredient, it has been made into pressed tablets, capsules, and many other dosage forms for the treatment of intestinal infections, diarrhea and other conditions.