D Mannose poudre en vrac

Qu’est-ce que D Mannose poudre en vrac?

La poudre de Mannose D est un monosaccharide. C’est un isomère du glucose qui pénètre dans les cellules par l’intermédiaire des protéines de transport du glucose. La Mannose est catalysée intracellulaire par l’hexokinase pour produire la mannose-6-phosphate (M6P), qui peut être catalysée par l’isomérase de la phosphomannose (PMI) pour entrer dans la voie glycolytique ou par la phosphomannose mutase (PMM2) pour entrer dans la voie de glycosylation.

D le mannose est présent à l’état libre dans les écorces de certaines plantes, comme dans les écorces d’agrumes, de petites quantités de mannose libre dans les fruits tels que les pêches et les pommes, et les glycans contenant du D-mannose dans les graines de palme ivoire, la levure, les algues rouges, la globuline sérique, la mucine d’œuf et Mycobacterium tuberculosis.

Green Spring Technologies produit D Mannose poudre en vrac Avec une grande pureté, une faible teneur en endotoxines, un faible nombre de colonies et de faibles métaux lourds. Il est testé pour les métaux lourds comme spécifié dans ICH Q3D à des concentrations aussi faibles que parties par milliard (PPB).

Le printemps vert a une excellente équipe de r & D, une équipe expérimentée de production, et une équipe professionnelle de ventes. Nous avons un système systématique de gestion de la qualité et organisons la production dans l’accord strict avec oin, HACCP, et d’autres normes de qualité. Nous avons passé Halal, casher, COSMOS, BRC, IFS, FDA, ISO, et beaucoup d’autres certifications. Nous pouvons fournir des rapports des essais faisant autorité de tiers.

Spécification: 

Règlements:

Il est conforme à la réglementation de l’ue.

Benefits:

Inhibiting Tumour Growth

A study reported in Nature 2018 found that D mannose powder can inhibit tumour growth by suppressing glucose metabolism by screening the effects of different hexoses on the growth of tumour cell lines. Lui Lei's team sought to explore whether various hexoses affect tumour immunity. Through screening, the researchers found that high concentrations of D-mannose were able to degrade PD-L1 protein in TNBC cells. In-depth mechanistic studies revealed that D-mannose treatment could promote the activation of AMPK, which promoted the phosphorylation of the S195 site of PD-L1 protein. The phosphorylation of this site can weaken the glycosylation of PD-L1 protein, which leads to the degradation of PD-L1 protein through proteasome.

Further studies revealed that D-mannose-mediated degradation of PD-L1 also inhibited the DNA damage repair process in tumour cells, resulting in a facilitating effect on radiotherapy for TNBC. In a mouse model of TNBC, the combination of oral D mannose and PD-1 antibody treatment significantly prolonged the survival of hormonal mice and increased CD8+ T cell infiltration and granzyme B expression in the tumour. Similarly, the combination of oral D-mannose and ionising radiation significantly inhibited tumour growth in vivo and significantly enhanced the efficacy of radiotherapy in TNBC mice.

In conclusion, this study revealed a new function of D-mannose - degradation of PD-L1 protein and reported for the first time the facilitating effect of D-mannose on immunotherapy and radiotherapy of TNBC, which provides a new strategy for the clinical treatment of TNBC.

Cell Recognition

D Mannose powder is one of the important components of cell surface glycosylation that can participate in cell recognition and interaction with the external environment.

Immunomodulation

D Mannose plays an important role in the immune system and is involved in intercellular signaling, inflammatory regulation, and activation of immune cells.

Antiviral

D mannose powder can interact with certain viral structural proteins to inhibit viral invasion and replication processes.

Applications:

For Feed Product：

Overuse of antibiotics in farming leads to the proliferation of resistant bacteria as well as pollution of the environment. Studies have demonstrated that D mannose powder can inhibit the infection of Salmonella in young chickens without side effects. Adding D mannose powder to livestock and poultry feed has the effect of inhibiting the proliferation of pathogens in the intestinal tract, protecting the health of animal intestinal tract, increasing immunity and disease resistance, and improving feed utilization.

For Health Products:

D Mannose powder has been used clinically as a glyconutrient. It can be widely distributed in body fluids and tissues, especially in the nerves, skin, testes, retina, liver, and intestine. The body can directly use mannose to synthesize glycoproteins and participate in immune regulation. In recent years, a series of surprising physiological activities of mannose, a common monosaccharide, have been revealed, including anti-inflammation, inhibition of bacterial infections, alleviation of diabetes, anti-tumor, etc. D mannose powder has been used as an additive in nutraceuticals.